The injector can work through clothing if needed. Sources: Kaleo, National Institutes of Health ALBERTO CUADRA AND BRADY DENNIS /THE WASHINGTON POST In synapses, molecules called neurotransmitters transfer impulses betweenbrain cells. Receptors in one end link with the neurotransmiters and pass the impulse. Evzio is a self-contained injection that counteracts the effects of opioids like heroin and oxycodone. Each device can be easily carried and delivers a dose of 0.4 mg of naloxone. 1 2 3 Opiates like heroin block some receptors, slowing down or stopping impulses between neurons. If too many of them are blocked, breathing may cease. Nervous impulses that control respiration are transmitted from the brain to the lungs through the spinal cord. Neurons exchange these signals in contact points called synapses. Naloxone knocks opioids from receptors, allowing more nervous signals between neurons. Reversing an Opioid Overdose Naloxone, a non-toxic, non-addictive medication that counteracts the effects of an opiate overdose, has been used for decades by paramedics and doctors. But the nation’s mounting death toll from drug overdoses has prompted a push to get the antidote in the hands of more first responders, as well as to friends and family members of opioid users. In April, the FDA approved the first naloxone auto-injector, Evzio, which makes it easy to administer the antidote even without training. Safety guard Indicatorwindow LED 2 in Using Evzio How naloxone works Evzio is activated by pulling the red safety guard at the bottom of the device. An electronic voice will guide the user on every step. The injector has to be placed against the outer thigh of the patient. A needle will come out from the base of the device and deliver a dose of naloxone. The needle retracts inside the device. A red LED light will blink, indicating the end of the procedure. The device cannot be reused. Opiate Synapse Impulse Neuron Naloxone Speaker Safety guard 2 in 3 3/8 in

SOURCE: Kaleo, National Institutes of Health.