0 0.2 0.4 0.6 0.8 1.0 1.2 1.4 $1.6billion 2008 2012 2011 2010 2009 Note: Because of issues in dosage and medical-claim coding for an unapproved use, the treatments and total cost of the less expensive drug are estimated from Medicare claims data based on known usage ratios. Figures are adjusted to 2012 dollars. Eylea is a new medication from a different manufacturer. Annual extra costEven though the least expensive drug is used most of the time, treatments for Medicare patients in the past five years have cost about $5.7 billion more than they would if the least expensive drug were used in all treatments, Washington Post calculations found. $1.6billion EyleaAbout $2,000 per dose LucentisAbout $2,000 per dose $50-$60 per dose Avastin $1.66billion Difference in cost if all treatments used Avastin $681million $899million $1.1billion $1.4billion Annual total cost In 2012 dollars Cost if all treatments used Avastin $767million $944million $1.22billion $1.45billion Total cost:

SOURCE: Washington Post analysis of Medicare Part B claims data.